Press Release

For Advion:
Kathryn Henion
Advion BioSciences, Inc.
607.266.0665
henionk@advion.com
http://www.advion.com

Brian J. Murphy
Waters Corporation
508.482.2614
brian_j_murphy@waters.com
http://www.waters.com

Media Contact:
Charles Versaggi, Ph.D.
Versaggi Biocommunications
415.397.3087
cv@versaggibio.com

June 9, 2003

Advion BioSciences and Waters Corporation to Co-Market Automated Nanoelectrospray™ to Life Science Market: Deal Advances Advion's Automated Nanoelectrospray Market Initiative

MONTREAL, June 09, 2003 — Advion BioSciences Inc., a leading provider of mass spectrometry (MS) services and products to the pharmaceutical industry, and Waters Corporation (NYSE:WAT), based in Milford, Mass., today announced a non-exclusive agreement to jointly promote their MS products to the life science research market. The co-marketing agreement was announced at the 51st annual meeting of the American Society for Mass Spectrometry (ASMS), held at Le Palais des Congrès de Montréal June 8 through June 12.

The agreement is part of Advion’s global market initiative to introduce the benefits of automated nanoelectrospray through strategic alliances with leading MS instrument manufacturers. Waters Corporation acquired U.K.-based Micromass Ltd. in 1997, establishing a market leadership position with combined strengths in high performance liquid chromatography (HPLC) and MS technologies.

Under the agreement, Advion and Waters will jointly market and co-promote their electrospray products and ensure compatibility of Advion’s NanoMate™ 100 automated nanoelectrospray system with the Waters® Micromass® MS Technologies mass spectrometers, including the Micromass LCT™, Quattro II™, Quattro micro™, Quattro Ultima™, Q-TofTM I™, Q-Tof II, Q-Tof micro™ and Q-Tof Ultima™ lines of liquid chromatography/mass spectrometry (LC/MS) systems. Advion and Waters will jointly coordinate the sales, marketing and support of the world’s first fully automated chip-based nanoelectrospray MS system. The agreement also defines the terms under which Advion and Waters will cooperate to develop and integrate Advion’s ChipSoftTM software with Waters MassLynx® software for seamless and flexible automated nanoelectrospray operation. Financial terms were not disclosed.

"The versatility and efficiency of our NanoMate 100 and ESI Chip™ technology are an excellent complement to Waters’ portfolio of electrospray MS systems. We are proud to be working with a recognized industry leader and innovator to bring automated nanoelectrospray to the life science market," said Jack Henion, Ph.D., Advion’s president and CEO.

"We are very pleased to deliver the power of automated nanoelectrospray to our LC/MS system users," said Brian Smith, senior director, pharmaceutical and life sciences market development at Waters. "Advion’s NanoMate enhances the speed and performance of applications in proteomics and small molecule analyses and will help us provide cutting-edge solutions to meet the continually evolving needs of our customers."

Automated Nanoelectrospray Provides Control of Both Analysis Speed and Data Quality

Advion’s NanoMate 100 robotic system and disposable ESI Chip allow users to take full advantage of the capabilities of electrospray mass spectrometry for life science applications. The NanoMate system enables a user to either speed analysis for increased throughput for small molecule and peptide mapping applications, or slow acquisition time for proteomics and metabolite identification applications where greater sample information is required. Key advantages include higher sample throughput, low sample consumption, high sensitivity, reduced analysis cost and the ability to derive meaningful results from a very small sample.

About Waters Corporation (www.waters.com)

Waters (NYSE:WAT) is a leading supplier of liquid chromatographs and mass spectrometers with applications in the life science and analytical chemistry markets. Waters Micromass MS Technologies are already recognized as an industry standard in the drug discovery & development and proteomics fields. The company reported revenues of $890 million in 2002 and employs nearly 3,500.

About Advion BioSciences Inc.

Founded in 1993, Advion BioSciences Inc., of Ithaca, N.Y., with a wholly-owned subsidiary in the United Kingdom, is a leading provider of mass spectrometry services to the pharmaceutical industry, and a developer of automated, chip-based technology designed to boost the sensitivity, data quality and sample throughput for electrospray mass spectrometers. The privately held company operates one of the world's largest LC/MS contract research facilities. Advion's clients include 13 of the top 15 pharmaceutical companies. For more information see www.advion.com.

Waters, Micromass, LCT, Quattro II, Quattro micro, Quattro Ultima, Q-Tof, Q-Tof Ultima, and MassLynx are trademarks of Waters Corporation.